Yaffe Lab Home

The Yaffe Lab is interested in understanding how protein kinase signaling pathways control cellular responses to injury, stress, and DNA damage.

The mural in the lobby of the Koch Institute (created by C.E.B Reas and Ben Fry) represents signaling networks and it is based on work from the Yaffe lab.

Research in the Yaffe lab continues to focus on how cell signaling events determine the response of tumor cells and innate immune cells to stress, cell injury and DNA damage.  The work is multi-disciplinary, using experimental and computational systems biology approaches, including biochemistry, structural and cell biology, and in vivo mouse models.  Translational applications of our research findings are influencing human cancer treatment, trauma care, and novel therapies for COVID-19-induced lung damage.