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The Yaffe Lab is interested in understanding how signaling pathways are integrated at the molecular and systems level to control cellular responses.

The mural in the lobby of the Koch Institute (created by C.E.B Reas and Ben Fry) represents signaling networks and it is based on work from the Yaffe lab.

Our interest has particularly focused on signaling pathways and networks that control cell cycle progression and DNA damage responses in cancer and cancer therapy, as well as the cross-talk between inflammation, cytokine signaling and cancer. Additionally, our work is directed to understanding how modular protein domains and kinases work together to build molecular signaling circuits. The research is multi-disciplinary and encompasses biochemistry, biophysics, structural and cell biology, engineering, and computation/bioinformatics.